Volume 1, Issue 4, October 2017, Page: 116-120
Antidiarrheal Potential of Adenanthera pavonina Linn Seed Aqueous Extract in Experimental Animals
Ramdas Pandhare, Department of Pharmacology, M. E. S’s College of Pharmacy, Savitribai Phule Pune University, Newasa, India
Sangameswaran Balakrishnan, S. S. M. College of Pharmacy, Erode, India
Gaurav Bangar, M. E. S’s College of Pharmacy, Savitribai Phule Pune University, Newasa, India
Pramod Dighe, M. E. S’s College of Pharmacy, Savitribai Phule Pune University, Newasa, India
Vinayak Deshmukh, M. E. S’s College of Pharmacy, Savitribai Phule Pune University, Newasa, India
Received: Apr. 4, 2017;       Accepted: May 6, 2017;       Published: Aug. 11, 2017
DOI: 10.11648/j.ijcm.20170104.12      View  1230      Downloads  60
Abstract
The objective of present investigation is to investigate antidiarrheal potential of Adenanthera pavonina seed aqueous extract (APSAE) in experimental animals. The APSAE was administered orally to three groups of animals (six per group) in order to investigate activity against castor oil and magnesium sulphate-induced diarrhoea in rats. The effect of extract on gastrointestinal transit using charcoal and castor oil induced enteropooling was assessed using Loperamide 3mg/kg was used as reference standard. Oral administration of APSAE at doses 50,100 and 200 mg/kg exhibited dose-dependent significant (P<0.05) antidiarrheal potential against castor oil and magnesium sulphate-induced diarrhoea in rats. APSAE also produced significant (P<0.05) reduction in propulsive movement in castor oil-induced gastrointestinal transit using charcoal meal in rats when compared with reference standard Loperamide. These findings demonstrate that Adenanthera pavonina seed aqueous extract shows significant antidiarrhoeal potential, thus justifying its traditional use in diarrhoea.
Keywords
Adenanthera pavonina, Diarrhoea, Castor Oil, MgSO4, Loperamide
To cite this article
Ramdas Pandhare, Sangameswaran Balakrishnan, Gaurav Bangar, Pramod Dighe, Vinayak Deshmukh, Antidiarrheal Potential of Adenanthera pavonina Linn Seed Aqueous Extract in Experimental Animals, International Journal of Chinese Medicine. Vol. 1, No. 4, 2017, pp. 116-120. doi: 10.11648/j.ijcm.20170104.12
Copyright
Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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