Volume 2, Issue 2, June 2018, Page: 6-13
Qizhi Decoction may Protect Diabetic Nephropathy Through Decrease Lipid and Inflammation
Cunyun Min, The Integrated Division of Chinese and Western Medicine, Guangdong Academy of Medical Sciences, Guangdong General Hospital, Guangdong Academy of Geriatrics, Guangzhou, China
Tingting Fu, The Integrated Division of Chinese and Western Medicine, Guangdong Academy of Medical Sciences, Guangdong General Hospital, Guangdong Academy of Geriatrics, Guangzhou, China
Xuhui Huang, The Integrated Division of Chinese and Western Medicine, Guangdong Academy of Medical Sciences, Guangdong General Hospital, Guangdong Academy of Geriatrics, Guangzhou, China
Yu Du, The Integrated Division of Chinese and Western Medicine, Guangdong Academy of Medical Sciences, Guangdong General Hospital, Guangdong Academy of Geriatrics, Guangzhou, China
Changjun Wang, The Integrated Division of Chinese and Western Medicine, Guangdong Academy of Medical Sciences, Guangdong General Hospital, Guangdong Academy of Geriatrics, Guangzhou, China
Received: Aug. 17, 2018;       Accepted: Sep. 12, 2018;       Published: Sep. 29, 2018
DOI: 10.11648/j.ijcm.20180202.11      View  258      Downloads  15
Abstract
Diabetic nephropathy (DN) affects approximately one-third of individuals with diabetes mellitus. Many patients develop kidney damage despite modern pharmacologic therapies available for DN treatment. Chinese medicine is a good choice for patients with DN. The aim of this study is to study the effect and safety of Qizhi decoction on patients with diabetic nephropathy. Approximately 255 men and women aged ≥18 to ≤80 years with DN were enrolled and randomized to two groups. The experimental intervention accepted Qizhi decoction in addition to their usual Novolin 50R penfill regimen. The control intervention accepted only Novolin 50R penfill. All participants receive their regimen for 12 weeks. Estimated glomerular filtration rate (eGFR), serum free fatty acid (FFA) level, the urine protein/creatinine ratio (U/C), plasma cystatin C (Cyst), Plasma C-reactive protein (CRP), hemoglobin A1c, serum uric acid, dyslipidemia were tested before entering the group. At the end of this study the index above and safety were measured again. Urine albumin levels, U/C, Cyst, CRP, FFA, TNF-α and MCP-1 levels decreased in both groups after 12 weeks of treatment. The eGFR, Cyst improved after12 weeks of treatment. Compared to the control, urine albumin levels, U/C, Cyst, CRP, FFA, TNF-α and MCP-1 levels decreased obviously in treatment group after 12 weeks of treatment. The kidney function, as measured by the eGFR, Cyst, significantly improved after12 weeks of treatment. The results indicate that combined Chinese and western medicine should be the better choice of patients with DN. QZD may protect Diabetic nephropathy through decrease lipid and inflammation.
Keywords
Diabetic Nephropathy, Albumin, Lipid, Inflammation, Kidney Function, Chinese Herbs
To cite this article
Cunyun Min, Tingting Fu, Xuhui Huang, Yu Du, Changjun Wang, Qizhi Decoction may Protect Diabetic Nephropathy Through Decrease Lipid and Inflammation, International Journal of Chinese Medicine. Vol. 2, No. 2, 2018, pp. 6-13. doi: 10.11648/j.ijcm.20180202.11
Copyright
Copyright © 2018 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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