Volume 4, Issue 3, September 2020, Page: 67-70
Advances in Immunotherapy and Molecular Targeted Therapy for Castration Resistant Prostate Cancer
Hai Hao, Department of Urology, Guang Zhou Red Cross Hospital, Guang Zhou, China; Medical College, Jinan University, Guang Zhou, China
Pan Wenhai, Department of Urology, Guang Zhou Red Cross Hospital, Guang Zhou, China; Medical College, Jinan University, Guang Zhou, China
Received: Aug. 31, 2020;       Accepted: Sep. 15, 2020;       Published: Sep. 23, 2020
DOI: 10.11648/j.ijcm.20200403.14      View  44      Downloads  20
Abstract
Background: Prostate cancer is one of the most common cancer threats to men. The incidence rate and mortality rate are second only to lung cancer in Europe and America. At present, the 5-year survival rate of prostate cancer is only 29% when metastasis occurs. Prostate cancer seriously endangers the health of male patients. Early prostate cancer surgery and radiotherapy and chemotherapy effect is better, advanced endocrine therapy effect is better, because of drug resistance, eventually progress to castration resistant prostate cancer (CRPC). Although new drugs such as abiraterone acetate, enzalutamide, apalutamide and darutamide have brought new hope to patients with CRPC, when CRPC progresses to metastatic castration resistant prostate cancer (mCRPC), the effect of endocrine therapy is limited. Objective: Immunotherapy, immunosuppressive checkpoint inhibitors and molecular targeted therapy bring new hope to patients with CRPC. This article will review the new progress of immunotherapy and molecular targeted therapy. Methods: A number of clinical and experimental studies were reviewed to indicate the novel advancement in the progressive therapy of CRPC. Results: Immunotherapy, immunosuppressive checkpoint inhibitors and molecular targeted therapy can improve median survival time and have a decrease of PSA level. Conclusion: With the advancements in CRPC therapy made by the researchers, some novel potential methods will occupy more and more important position in the treatment of CRPC.
Keywords
Castration Resistant Prostate Cancer, Immunotherapy, Molecular Targeted Therapy
To cite this article
Hai Hao, Pan Wenhai, Advances in Immunotherapy and Molecular Targeted Therapy for Castration Resistant Prostate Cancer, International Journal of Chinese Medicine. Vol. 4, No. 3, 2020, pp. 67-70. doi: 10.11648/j.ijcm.20200403.14
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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