Comparison of Drug-eluting Balloon Versus Drug-eluting Stent in de Novo Coronary Artery Disease: A Systematic Review and Meta-analysis

Cao Mingkun; Yinyuxia; Wang Zhiyong; Zhang Haijun

doi:doi:10.11648/j.ijcm.20220601.12

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Comparison of Drug-eluting Balloon Versus Drug-eluting Stent in de Novo Coronary Artery Disease: A Systematic Review and Meta-analysis

Cao Mingkun, Yinyuxia, Wang Zhiyong, Zhang Haijun

Published in International Journal of Chinese Medicine (Volume 6, Issue 1)

Received: 1 September 2021 Accepted: 16 September 2021 Published: 28 January 2022

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Abstract

Background: Drug- eluting balloon (DEB) and drug- eluting stent (DES) are widely used in cardiovascular interventional surgery. But the long-term safety of DEB is unclear. Objective: To compare the efficacy and safety of DEB with DES for the treatment of de novo coronary artery disease (CAD). Methods: We conducted a meta-analysis of relevant studies identified in the Pubmed, Embase, and Cochrane Library databases. Random and fixed effects models were used to calculate the relative risks (RR) and standard mean differences (SMD) with 95% confidence intervals. Results: Nine studies in 1946 patients were included in this analysis. There was no significant difference in the primary endpoint of major adverse cardiovascular events (MACE) or in the efficacy endpoint of late lumen loss (LLL) between the DEB and DES groups. For follow-up < 12 months, there was no significant difference between DEB and DES for each MACE component, including target lesion revascularization (TLR), stent thrombosis (ST), myocardial infarction (MI), and death. However, a lower risk for MI and death was observed for DEB when the follow-up time was ≥ 12 months. Conclusion: DEB is equivalent to DES for the treatment of patients with de novo CAD and appears to represent a safer option for long-term treatment of this patient population.

Published in	International Journal of Chinese Medicine (Volume 6, Issue 1)
DOI	10.11648/j.ijcm.20220601.12
Page(s)	8-14
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Drug-eluting Balloon, Drug-eluting Stent, De Novo Coronary Artery Disease

References

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APA Style

Cao Mingkun, Yinyuxia, Wang Zhiyong, Zhang Haijun. (2022). Comparison of Drug-eluting Balloon Versus Drug-eluting Stent in de Novo Coronary Artery Disease: A Systematic Review and Meta-analysis. International Journal of Chinese Medicine, 6(1), 8-14. https://doi.org/10.11648/j.ijcm.20220601.12

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ACS Style

Cao Mingkun; Yinyuxia; Wang Zhiyong; Zhang Haijun. Comparison of Drug-eluting Balloon Versus Drug-eluting Stent in de Novo Coronary Artery Disease: A Systematic Review and Meta-analysis. Int. J. Chin. Med. 2022, 6(1), 8-14. doi: 10.11648/j.ijcm.20220601.12

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AMA Style

Cao Mingkun, Yinyuxia, Wang Zhiyong, Zhang Haijun. Comparison of Drug-eluting Balloon Versus Drug-eluting Stent in de Novo Coronary Artery Disease: A Systematic Review and Meta-analysis. Int J Chin Med. 2022;6(1):8-14. doi: 10.11648/j.ijcm.20220601.12

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@article{10.11648/j.ijcm.20220601.12,
  author = {Cao Mingkun and Yinyuxia and Wang Zhiyong and Zhang Haijun},
  title = {Comparison of Drug-eluting Balloon Versus Drug-eluting Stent in de Novo Coronary Artery Disease: A Systematic Review and Meta-analysis},
  journal = {International Journal of Chinese Medicine},
  volume = {6},
  number = {1},
  pages = {8-14},
  doi = {10.11648/j.ijcm.20220601.12},
  url = {https://doi.org/10.11648/j.ijcm.20220601.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcm.20220601.12},
  abstract = {Background: Drug- eluting balloon (DEB) and drug- eluting stent (DES) are widely used in cardiovascular interventional surgery. But the long-term safety of DEB is unclear. Objective: To compare the efficacy and safety of DEB with DES for the treatment of de novo coronary artery disease (CAD). Methods: We conducted a meta-analysis of relevant studies identified in the Pubmed, Embase, and Cochrane Library databases. Random and fixed effects models were used to calculate the relative risks (RR) and standard mean differences (SMD) with 95% confidence intervals. Results: Nine studies in 1946 patients were included in this analysis. There was no significant difference in the primary endpoint of major adverse cardiovascular events (MACE) or in the efficacy endpoint of late lumen loss (LLL) between the DEB and DES groups. For follow-up Conclusion: DEB is equivalent to DES for the treatment of patients with de novo CAD and appears to represent a safer option for long-term treatment of this patient population.},
 year = {2022}
}

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TY  - JOUR
T1  - Comparison of Drug-eluting Balloon Versus Drug-eluting Stent in de Novo Coronary Artery Disease: A Systematic Review and Meta-analysis
AU  - Cao Mingkun
AU  - Yinyuxia
AU  - Wang Zhiyong
AU  - Zhang Haijun
Y1  - 2022/01/28
PY  - 2022
N1  - https://doi.org/10.11648/j.ijcm.20220601.12
DO  - 10.11648/j.ijcm.20220601.12
T2  - International Journal of Chinese Medicine
JF  - International Journal of Chinese Medicine
JO  - International Journal of Chinese Medicine
SP  - 8
EP  - 14
PB  - Science Publishing Group
SN  - 2578-9473
UR  - https://doi.org/10.11648/j.ijcm.20220601.12
AB  - Background: Drug- eluting balloon (DEB) and drug- eluting stent (DES) are widely used in cardiovascular interventional surgery. But the long-term safety of DEB is unclear. Objective: To compare the efficacy and safety of DEB with DES for the treatment of de novo coronary artery disease (CAD). Methods: We conducted a meta-analysis of relevant studies identified in the Pubmed, Embase, and Cochrane Library databases. Random and fixed effects models were used to calculate the relative risks (RR) and standard mean differences (SMD) with 95% confidence intervals. Results: Nine studies in 1946 patients were included in this analysis. There was no significant difference in the primary endpoint of major adverse cardiovascular events (MACE) or in the efficacy endpoint of late lumen loss (LLL) between the DEB and DES groups. For follow-up Conclusion: DEB is equivalent to DES for the treatment of patients with de novo CAD and appears to represent a safer option for long-term treatment of this patient population.
VL  - 6
IS  - 1
ER  -

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Author Information

Cao Mingkun

National United Engineering Laboratory for Biomedical Material Modification, Dezhou, China
Yinyuxia

National United Engineering Laboratory for Biomedical Material Modification, Dezhou, China
Wang Zhiyong

Inner Mongolia People's Hospital, Hohhot, China
Zhang Haijun

National United Engineering Laboratory for Biomedical Material Modification, Dezhou, China

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Plain Text BibTeX RIS

APA Style

Cao Mingkun, Yinyuxia, Wang Zhiyong, Zhang Haijun. (2022). Comparison of Drug-eluting Balloon Versus Drug-eluting Stent in de Novo Coronary Artery Disease: A Systematic Review and Meta-analysis. International Journal of Chinese Medicine, 6(1), 8-14. https://doi.org/10.11648/j.ijcm.20220601.12

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ACS Style

Cao Mingkun; Yinyuxia; Wang Zhiyong; Zhang Haijun. Comparison of Drug-eluting Balloon Versus Drug-eluting Stent in de Novo Coronary Artery Disease: A Systematic Review and Meta-analysis. Int. J. Chin. Med. 2022, 6(1), 8-14. doi: 10.11648/j.ijcm.20220601.12

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AMA Style

Cao Mingkun, Yinyuxia, Wang Zhiyong, Zhang Haijun. Comparison of Drug-eluting Balloon Versus Drug-eluting Stent in de Novo Coronary Artery Disease: A Systematic Review and Meta-analysis. Int J Chin Med. 2022;6(1):8-14. doi: 10.11648/j.ijcm.20220601.12

Copy | Download

@article{10.11648/j.ijcm.20220601.12,
  author = {Cao Mingkun and Yinyuxia and Wang Zhiyong and Zhang Haijun},
  title = {Comparison of Drug-eluting Balloon Versus Drug-eluting Stent in de Novo Coronary Artery Disease: A Systematic Review and Meta-analysis},
  journal = {International Journal of Chinese Medicine},
  volume = {6},
  number = {1},
  pages = {8-14},
  doi = {10.11648/j.ijcm.20220601.12},
  url = {https://doi.org/10.11648/j.ijcm.20220601.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcm.20220601.12},
  abstract = {Background: Drug- eluting balloon (DEB) and drug- eluting stent (DES) are widely used in cardiovascular interventional surgery. But the long-term safety of DEB is unclear. Objective: To compare the efficacy and safety of DEB with DES for the treatment of de novo coronary artery disease (CAD). Methods: We conducted a meta-analysis of relevant studies identified in the Pubmed, Embase, and Cochrane Library databases. Random and fixed effects models were used to calculate the relative risks (RR) and standard mean differences (SMD) with 95% confidence intervals. Results: Nine studies in 1946 patients were included in this analysis. There was no significant difference in the primary endpoint of major adverse cardiovascular events (MACE) or in the efficacy endpoint of late lumen loss (LLL) between the DEB and DES groups. For follow-up Conclusion: DEB is equivalent to DES for the treatment of patients with de novo CAD and appears to represent a safer option for long-term treatment of this patient population.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Comparison of Drug-eluting Balloon Versus Drug-eluting Stent in de Novo Coronary Artery Disease: A Systematic Review and Meta-analysis
AU  - Cao Mingkun
AU  - Yinyuxia
AU  - Wang Zhiyong
AU  - Zhang Haijun
Y1  - 2022/01/28
PY  - 2022
N1  - https://doi.org/10.11648/j.ijcm.20220601.12
DO  - 10.11648/j.ijcm.20220601.12
T2  - International Journal of Chinese Medicine
JF  - International Journal of Chinese Medicine
JO  - International Journal of Chinese Medicine
SP  - 8
EP  - 14
PB  - Science Publishing Group
SN  - 2578-9473
UR  - https://doi.org/10.11648/j.ijcm.20220601.12
AB  - Background: Drug- eluting balloon (DEB) and drug- eluting stent (DES) are widely used in cardiovascular interventional surgery. But the long-term safety of DEB is unclear. Objective: To compare the efficacy and safety of DEB with DES for the treatment of de novo coronary artery disease (CAD). Methods: We conducted a meta-analysis of relevant studies identified in the Pubmed, Embase, and Cochrane Library databases. Random and fixed effects models were used to calculate the relative risks (RR) and standard mean differences (SMD) with 95% confidence intervals. Results: Nine studies in 1946 patients were included in this analysis. There was no significant difference in the primary endpoint of major adverse cardiovascular events (MACE) or in the efficacy endpoint of late lumen loss (LLL) between the DEB and DES groups. For follow-up Conclusion: DEB is equivalent to DES for the treatment of patients with de novo CAD and appears to represent a safer option for long-term treatment of this patient population.
VL  - 6
IS  - 1
ER  -

Copy | Download