Fine Analysis of the Binding Mode Between Traditional Chinese Chemical Components and 2019-nCoV RNA Polymerase Based on Molecular Docking Technology
Ji-chao Wei,
Qian Liu,
Yan-Lei Su,
An-Tang Peng,
Xu-Hong Duan
Issue:
Volume 6, Issue 2, June 2022
Pages:
20-33
Received:
28 May 2022
Accepted:
5 July 2022
Published:
20 July 2022
DOI:
10.11648/j.ijcm.20220602.11
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Abstract: Sing SARS RNA polymerase 6NUR as a template, a three-dimensional structural model of the novel coronavirus’ RNA polymerase was constructed with a homology modeling approach. It was used as an antiviral research target and refined to analyze the molecular interaction between amino acid and substrate inhibitors in target enzyme NTPs binding sites. The virtual screening showed that flavonoids are novel coronavirus resistant active ingredients. The results of the study proved to be highly relevant to antiviral clinical practice and consistent with the fact that some flavonoids are NS5B inhibitors and thus have anti-HCV activity. We hope that our report will attract the attention of researchers at home and abroad, and through further experimental validation, it will help us to develop better anti-novel coronavirus drugs as soon as possible.
Abstract: Sing SARS RNA polymerase 6NUR as a template, a three-dimensional structural model of the novel coronavirus’ RNA polymerase was constructed with a homology modeling approach. It was used as an antiviral research target and refined to analyze the molecular interaction between amino acid and substrate inhibitors in target enzyme NTPs binding sites. Th...
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A Case Report of Comprehensive Detumescence Therapy Combined with Traditional Chinese Medicine in the Treatment of Lymphedema After Endometrial Cancer
Hu Shi-si,
Xiong Zhi-feng,
Gao Yuan,
Gan Lin
Issue:
Volume 6, Issue 2, June 2022
Pages:
34-39
Received:
16 May 2022
Accepted:
2 June 2022
Published:
12 August 2022
DOI:
10.11648/j.ijcm.20220602.12
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Views:
Abstract: Background: Endometrial cancer is one of the most common tumors in the female reproductive system, and lower limb edema is one of the common complications after endometrial cancer. Long term lower limb edema leads to serious aggravation of patients' life dependence and affects their quality of life; It is difficult for patients to live independently without their families, resulting in psychological anxiety and even depression. Objective: to introduce the application of comprehensive detumescence therapy combined with traditional Chinese medicine in the treatment of lymphedema after endometrial cancer operation. METHODS: 1 Case of Lower Limb lymphedema after endometrial cancer operation was collected, and according to the specific swelling condition and degree of the patients, the reasonable comprehensive detumescence therapy and TCM treatment plan were made. The methods of treatment were manual lymphatic drainage, low-stretch elastic bandage, extracorporeal shock wave apparatus and pneumatic limb blood circulation therapy, combined with acupoint therapy and external application of traditional Chinese medicine. The patient was evaluated for recovery after 1 month of treatment. Results: The combined swelling therapy and internal application of traditional Chinese medicine relieved the swelling in the short time. Conclusion: The effect of postoperative lymphoedema swelling is definite and worth promotion.
Abstract: Background: Endometrial cancer is one of the most common tumors in the female reproductive system, and lower limb edema is one of the common complications after endometrial cancer. Long term lower limb edema leads to serious aggravation of patients' life dependence and affects their quality of life; It is difficult for patients to live independentl...
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